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The Oxford Handbook of Neuronal Protein Synthesis
Regular Price
$330.95
Special Price
$297.86
$270.78
Oxford Handbooks
- An up to date summary of how protein synthesis is regulated in the nervous system, written by experts in the field.
- Comprehensive overviews of the role translation plays in physiological and pathological processes in the nervous system.
- Articles provide provocative new ideas about outstanding questions in the field.
ISBN: 9780190686307
Stock Status:
12 – 16 weeks delivery
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In stock
SKU
9780190686307
Translational control in the nervous system is important. Many physiological processes in the nervous system depend on accurate control of the proteome that is mediated through protein synthetic mechanisms and thus, the nervous system is very sensitive to dysregulation of translational control. The Oxford Handbook of Neuronal Protein Synthesis reviews the mechanisms of translational control used by the nervous system, as well as how important nervous system functions, such as plasticity and homeostasis, depend on accurate translational control. The handbook extensively covers how dysregulation of protein synthesis can manifest itself in many distinct pathological processes including neurodevelopmental, neuropsychiatric, and neurodegenerative diseases. The handbook is comprehensive in its coverage of translational control mechanisms with particular focus on how these general control mechanisms are specifically utilized in the context of the cell biological constraints of the nervous system from both a mechanistic and systems perspective.
| Author | Wayne S. Sossin |
|---|---|
| Table Of Content | Part I: Role of Translation Factors 1. Regulation of Protein Synthesis by eIF4E in the Brain Kleanthi Chalkiadaki, Stella Kouloulia, Clive R. Bramham, and Christos G. Gkogkas 2. Translational Control Through the eIF4E Binding Proteins in the Brain Argel Aguilar-Valles, Edna Matta-Camacho, and Nahum Sonenberg 3. The Integrated Stress Response in Memory and Cognitive Disorders Jacqunae L. Mays and Mauro Costa-Mattioli 4. The Role of the Eukaryotic Elongation Factor 2 (eEF2) Pathway in Neuronal Function Elham Taha and Kobi Rosenblum 5. Sidekick No More: Neural Translation Control by p70 ribosomal S6 kinase 1 Aditi Bhattacharya Part II: Role of Specific Elements in the mRNA 6. Dendritic Targeting and Regulatory RNA Control of Local Neuronal Translation Taesun Eom, Ilham A. Muslimov, Anna Iacoangeli, and Henri Tiedge 7. Internal Ribosome Entry Site-Mediated Translation in Neuronal Protein Synthesis Martin Holcik 8. RNA Modifications in the Central Nervous System Dan Ohtan Wang 9. Role of CPEB-Family Proteins in Memory Kausik Si 10. FMRP and MicroRNAs in Neuronal Protein Synthesis Monica C. Lannom and Stephanie Ceman 11. Focusing on mRNA Granules and Stalled Polysomes Amidst Diverse Mechanisms Underlying mRNA Transport, mRNA Storage and Local Translation Mina N. Anadolu and Wayne S. Sossin Part III: Physiological Roles of Translation 12. Protein Synthesis and Synapse Specificity in Functional Plasticity Radha Raghuraman, Amrita Benoy, and Sreedharan Sajikumar 13. Regulation of Synaptic Homeostasis by Translational Mechanisms Megumi Mori, Jay Penney, and Pejmun Haghighi 14. Multiple Roles of RNA Regulatory Factors in Neuronal Development and Function in C. elegans Matthew G. Andrusiak and Yishi Jin 15. Regulation of mRNA Translation in Axons Priyanka Patel, Pabitra K. Sahoo, Amar N. Kar, and Jeffery L. Twiss 16. Protein Synthesis and Translational Control in Neural Stem Cell Development and Neurogenesis Lamees Mohammad, Joscelyn Wiseman, Sarah Erickson, and Guang Yang Part IV: Neuronal Protein Synthesis and Disease 17. Translational Controls in Pain Sarah Loerch, June Bryan De La Peña, Jane Song, Joseph J. Pancrazio, Theodore J. Price, and Zachary T. Campbell 18. Dysregulated Translation in Autism Spectrum Disorder Emanuela Santini and Anders Borgkvist 19. Neuronal mRNA Translation in Addiction Emma Puighermanal and Emmanuel Valjent 20. Dysregulated Protein Synthesis in Major Depression Disorder Chelcie F. Heaney and Kimberly F. Raab-Graham 21. Dysregulation of Neuronal Protein Synthesis in Alzheimer's Disease Tao Ma 22. RNA-Binding Proteins and Translation in Neurodegenerative Disease Kent E. Duncan 23. Role of Eukaryotic Initiation Factor eIF2B in Vanishing White Matter Disease Truus E. M. Abbink, Lisanne E. Wisse, Xuemin Wang, and Christopher G. Proud Index |
| Publish Date | 26 Aug 2021 |
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