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Globalization and Health Recivilizing Germans, 1945-1995

Globalization and Health Recivilizing Germans, 1945-1995

Measuring Health A Guide to Rating Scales and Questionnaires

Measuring Health A Guide to Rating Scales and Questionnaires

Neural Tube Defects From Origin to Treatment

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9780195166033
 

Neural tube defects affect about 4000 pregnancies a year and are thus among the most common of severe birth defects. Prenatal diagnosis can now detect about 70% of neural tube defects, but the tests produce many false positives, so the question is under what circumstances should they be recommended to pregnant women. This comprehensive volume - the collective knowledge of more than fifty-five experts in the field - provides lucid and authoritative discussions on this topic as well as on a wide variety of theoretical, experimental and clinical issues.

The book is divided into three sections. Section I addresses embryology of the central nervous system, clinical features, epidemiology, and the genetics of neural tube defects. Providing a strong explanation of the mechanisms involved in NTDs formation and the genetic and environmental factors involved in their etiology, it guides the reader through the steps of diagnosis and the classification of the different types of NTDs. Section II describes in detail the assessment and treatment of the needs of individuals with NTDs. Prenatal and postnatal surgical techniques, orthopedic and urological management, genetic counselling and communication, psychological adjustment, and the transition to adulthood (including sexuality and toilet training) for patients with spina bifida are discusses. Section III presents new areas of emerging interest to society-at-large, such as how and when to fortify foods to prevent NTDs, the costs of treatment of individuals with NTDs, coverage of health care, quality of life, and the ethics of contemporary medical management. Written with a wide readership in mind, this book will be of interest to geneticists, paediatricians, neurologists, internists, graduate students, researchers interested in the field of birth defects, as well as to individuals with NTDs and their family members.

More Information
Author WYSZYNSKI
Table Of Content

Foreword
Section I: Basic principles
Part 1: Clinical and molecular embryology of the central nervous system
1: Neural crest formation
2: The embryonic basis of neural tube defects
3: The zebrafish as a model for analyzing neural tube defects
4: Genetic regulation of early nervous system development
Part 2: Clinical features of neural tube defects
5: Physical examination of the spine
6: Classification of neural tube defects
7: Syndromes with neural tube defects
8: The tethered cord syndrome
9: Prenatal screening and diagnosis of neural tube defects
Part 3: Epidemiology of neural tube defects
10: Methodological issues in the study of neural tube defects
11: Birth defects surveillance systems and neural tube defects
12: An international perspective on anencephaly and spina bifida: Prevalences by the turn of the century
13: Maternal exposure to selected environmental factors and risk for neural tube defects in the offspring
Part 4: Genetics of neural tube defects
14: Nonsyndromic neural tube defects: genetic basis and genetic investigations
15: Genetic risk factors for neural tube defects: variants in folate metabolism
16: Genetics of syndromic neural tube defects
17: Mouse mutants as models of neural tube defects
Section II: Treatment and education
18: Fetal surgery for myelomeningocele
19: Postnatal surgery for myelomeningocele
20: Neurosurgical management of adults with spina bifida
21: Orthopedic surgery
22: Urological care and management of patients with neural tube defects
23: Cognition, education and learning disorders
24: Transition to adulthood
25: Transition/toilet training, and sexuality
26: Psychological adjustment and family relationships in children and adolescents with spina bifida
27: When and how to communicate to people with spina bifida and their families
28: Genetic counselling and interpretation of risk figures
Section III: Public health issues
29: Preventing all folic acid-preventable spina bifida
30: The half-life of cost-of-illness estimates: the case of spina bifida
31: Insurance and coverage of care for individuals with spina bifida and other neural tube defects
32: Assessment of health-related quality of life in individuals with neural tube defects
33: Ethics at the forefront: moral decisions and responsibility when confronted with spina bifida

Publish Date 1 Dec 2005
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