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Mayo Clinic Neurology Board Review: Basic Sciences and Psychiatry for Initial Certification Contributors Continuing Medical Education Information Faculty, Planning Committee and Provider Disclosure Summary Section I: Neuroscience and Neuroanatomy, Eduardo E. Benarroch, MD, editor 1 Cerebrovascular Anatomy and Pathophysiology Kelly D. Flemming, MD 2 Meninges and Ventricles Ruple S. Laughlin, MD; and Kelly D. Flemming, MD 3 Afferent System Overview Kelly D. Flemming, MD; and Eduardo E. Benarroch, MD 4 Peripheral and Central Pain Pathways and Pathophysiology Eduardo E. Benarroch, MD; James C. Watson, MD; and Kelly D. Flemming, MD 5 Special Somatic Sensory Afferent Overview Scott D. Eggers, MD; Eduardo E. Benarroch, MD; and Jacqueline A. Leavitt, MD 6 Peripheral Nerve, Neuromuscular Junction, and Muscle Anatomy Jennifer A. Tracy, MD 7 Spinal Cord Anatomy Jennifer A. Tracy, MD 8 Brainstem and Cranial Nerves: Overview and Medulla Kelly D. Flemming, MD 9 Brainstem and Cranial Nerves: The Pons Kelly D. Flemming, MD; and Paul W. Brazis, MD 10 Brainstem and Cranial Nerves: The Midbrain Kelly D. Flemming, MD; and Paul W. Brazis, MD 11 Brainstem and Cranial Nerves: Longitudinal Brainstem Kelly D. Flemming, MD; and Paul W. Brazis, MD 12 Supranuclear Ocular Motor Systems Paul W. Brazis, MD; and Scott D. Eggers, MD 13 Cranial Nerves I and II Kelly D. Flemming, MD; Jacqueline A. Leavitt, MD; and Eduardo E. Benarroch, MD 14 Thalamus Kelly D. Flemming, MD; and Eduardo E. Benarroch, MD 15 Principles of Neuroendocrinology and Hypothalamic Function Elizabeth A. Coon, MD; and Eduardo E. Benarroch, MD 16 The Limbic System Kelly D. Flemming, MD; and Eduardo E. Benarroch, MD 17 Basal Ganglia Jonathan Graff-Radford, MD; Alex J. Nelson, MD; and Eduardo E. Benarroch, MD 18 Cerebellum Jonathan Graff-Radford, MD; Anhar Hassan, MB, BCh; and Eduardo E. Benarroch, MD 19 Autonomic Nervous System Jennifer A. Tracy, MD; Eduardo E. Benarroch, MD; and Kelly D. Flemming, MD 20 Cortex: Gross Anatomy Kelly D. Flemming, MD 21 Cortex Topography and Organization Richard J. Caselli, MD; and David T. Jones, MD 22 Cortical Circuitry, Networks, and Function David T. Jones, MD 23 Focal Cognitive Syndromes Richard J. Caselli, MD Questions and Answers Section II: Cellular Neuroscience, Eduardo E. Benarroch, MD, editor 24 Cellular Signaling Nathan P. Staff, MD, PhD 25 Cellular Processes Nathan P. Staff, MD, PhD 26 Cellular Injury and Death Brian S. Katz, MD; and Eduardo E. Benarroch, MD Questions and Answers Section III: Neuropharmacology, Jeffrey W. Britton, MD, editor Questions and Answers 27 Neuropharmacology Amy Z. Crepeau, MD; and Jeffrey W. Britton, MD Questions and Answers Section IV: Sleep Pathophysiology, Pablo R. Castillo, MD, editor 28 Sleep Pathophysiology Michael F. Presti, MD, PhD Questions and Answers Section V: Neurogenetics, Ralitza H. Gavrilova, MD, editor 29 Patterns of Inheritance in Neurogenetic Disease Ralitza H. Gavrilova, MD; and Virginia V. Michels, MD 30 Chromosomal Syndromes Ralitza H. Gavrilova, MD; and Virginia V. Michels, MD Questions and Answers Section VI: Neurodiagnostics, Ruple S. Laughlin, MD, editor 31 Electroencephalography David B. Burkholder, MD; and Jeffrey W. Britton, MD 32 Nerve Conduction Studies and Needle Electromyography Brian A. Crum, MD 33 Cerebrospinal Fluid Ruple S. Laughlin, MD 34 Evoked Potentials James C. Watson, MD 35 Neuroimaging David F. Black, MD Questions and Answers Section VII: Psychiatry, Kemuel L. Philbrick, MD, editor 36 Principles of Psychiatry and Psychology Mary M. Machulda, PhD, LP 37 Psychological Development Through the Life Cycle Maria I. Lapid, MD; and Mark W. Olsen, MD 38 Mood Disorders Simon Kung, MD 39 Anxiety Disorders Michael M. Reese, MD 40 Psychotic Disorders Keith G. Rasmussen, MD 41 Personality and Illness Brian A. Palmer, MD 42 Miscellaneous Psychiatric Disorders Kari A. Martin, MD 43 Psychiatric Disorders Associated With Infancy, Childhood, and Adolescence Jyoti Bhagia, MD 44 Substance Use Disorders Tamara J. Dolenc, MD 45 Pharmacologic Treatment of Psychiatric Disorders Osama A. Abulseoud, MD 46 Nonpharmacologic Treatment of Psychiatric Disorders Jarrod M. Leffler, PhD, LP Questions and Answers Index Mayo Clinic Neurology Board Review: Clinical Neurology for Initial Certification and MOC Contributors Continuing Medical Education Information Faculty, Planning Committee and Provider Disclosure Summary Section I: Neurology Intensive Care Eelco F. M. Wijdicks, MD, editor 1 Impaired Consciousness and Coma S. Arthur Moore, MD; and Eelco F. M. Wijdicks, MD 2 Principles and Management of Alterations in Intracranial Pressure Heidi T. Woessner, MD; and William D. Freeman, MD 3 Status Epilepticus Sara E. Hocker, MD; and Matthew T. Hoerth, MD 4 Nontraumatic Subarachnoid Hemorrhage Jennifer E. Fugate, DO; and Eelco F.M. Wijdicks, MD, PhD 5 Anoxic-Ischemic Encephalopathy Jennifer E. Fugate, DO; and Eelco F.M. Wijdicks, MD, PhD 6 Traumatic Brain Injury Jeffrey T. Jacob, MD; and Eelco F.M. Wijdicks, MD, PhD 7 Acute Spinal Cord Compression, Spinal Cord Trauma, and Peripheral Nerve Injury Patrick R. Maloney, MD; Jeffrey T. Jacob, MD; and Eelco F.M. Wijdicks, MD, PhD 8 Neuromuscular Disease in the Neuroscience Intensive Care Unit Philippe Couillard, MD; and Eelco F. M. Wijdicks, MD, PhD 9 Acute Hyperthermic Syndromes Philippe Couillard, MD; and Eelco F. M. Wijdicks, MD, PhD Section II: Cerebrovascular Diseases Kevin M. Barrett, MD, editor 10 Ischemic Stroke: Common Causes and Diagnosis Kelly D. Flemming, MD 11 Ischemic Stroke: Uncommon and Special Situations Kelly D. Flemming, MD 12 Acute Ischemic Stroke Evaluation and Treatment Bart M. Demaerschalk, MD 13 Secondary Prevention of Ischemic Stroke Bart M. Demaerschalk, MD 14 Intraparenchymal Cerebral Hemorrhage Maria I. Aguilar, MD; and Barry D. Birch, MD 15 Unruptured Intracranial Aneurysms and Vascular Malformations Robert D. Brown Jr, MD, MPH 16 Neurorehabilitation Billie A. Schultz, MD Questions and Answers Section III: Demyelinating Diseases B. Mark Keegan, MD, editor 17 Pathology and Spectrum of Central Nervous System Inflammatory Demyelinating Diseases Claudia F. Lucchinetti, MD 18 The Diagnosis of Multiple Sclerosis Istvan Pirko, MD 19 Treatment of Multiple Sclerosis Orhun H. Kantarci, MD 20 Mimickers of Multiple Sclerosis Jessica P. Floyd, MD; and Elizabeth A. Shuster, MD Questions and Answers Section IV: Movement Disorders Bryan T. Klassen, MD, editor 21 Classification and Approach to Movement Disorders Paul E. Youssef, DO; Kenneth J. Mack, MD, PhD; and Kelly D. Flemming, MD 22 Hypokinetic Movement Disorders: Parkinson Disease Alex J. Nelson, MD; and Bryan T. Klassen, MD 23 Atypical Parkinsonian Syndromes Jeremy K. Cutsforth-Gregory, MD; Bradley F. Boeve, MD; and Keith A. Josephs, MD 24 Hyperkinetic Movement Disorders: Tremor and Myoclonus Melinda S. Burnett, MD 25 Hyperkinetic Movement Disorders: Chorea, Tic, and Dystonia Elizabeth A. Coon, MD; and James H. Bower, MD 26 Cerebellar Disorders and Ataxia Anhar Hassan, MB, BCh 27 Childhood Movement Disorders Paul E. Youssef, DO; and Kenneth J. Mack, MD, PhD Questions and Answers Section V: Behavioral Neurology Bryan Woodruff, MD, editor 28 Syndromes of Cognitive Dysfunction Kelly D. Flemming, MD 29 A Review of Focal Cortical Syndromes Kelly D. Flemming, MD; and Richard J. Caselli, MD 30 Mild Cognitive Impairment and Alzheimer Disease Qurat ul Ain Khan, MD; and Nilüfer Taner, MD, PhD 31 Frontotemporal Dementias Shinsuke Fujioka, MD; Neill R. Graff-Radford, MD; Daniel F. Broderick, MD; and Zbigniew K. Wszolek, MD 32 Parkinsonism-Related Dementias Bradley F. Boeve, MD 33 Nondegenerative Dementias and Encephalopathies Eoin P. Flanagan, MB, BCh Questions and Answers Section VI: Epilepsy Katherine H. Noe, MD, editor 34 Epilepsy Classification Kristine S. Ziemba, MD, PhD; and Katherine H. Noe, MD, PhD 35 Epidemiology and Pathophysiology of Epilepsy Katherine H. Noe, MD, PhD 36 Evaluating Seizures and Seizurelike Events Joseph F. Drazkowski, MD 37 Treatment of Epilepsy Matthew T. Hoerth, MD Questions and Answers Section VII: Neuromuscular and Spine Disorders Elliot L. Dimberg, MD, editor 38 Myelopathies Patty P. Atkinson, MD; and Jessica P. Floyd, MD 39 Motor Neuron Diseases Eric J. Sorenson, MD 40 Peripheral Nerve Disorders Sarah E. Berini, MD; and Nathan P. Staff, MD, PhD 41 Neuromuscular Junction Disorders Brent P. Goodman, MD 42 Acquired Muscle Disorders Margherita Milone, MD, PhD 43 Inherited Muscle Disorders Margherita Milone, MD, PhD 44 Autonomic Disorders Wolfgang Singer, MD Questions and Answers Section VIII: Clinical Disorders of the Cranial Nerves and Brainstem Carrie E. Robertson, MD, editor 45 Neuro-ophthalmology: Visual Fields Jacqueline A. Leavitt, MD 46 Neuro-ophthalmology: Disorders of Visual Perception, Pupils, and Eyelids Kelly D. Flemming, MD 47 Neuro-ophthalmology: Extraocular Muscles and Cranial Nerves III, IV, and VI Paul W. Brazis, MD 48 Clinical Neurotology Scott D. Eggers, MD 49 Disorders of the Cranial Nerves and Brainstem Kelly D. Flemming, MD Questions and Answers Section IX: Headache and Pain Christopher J. Boes, MD, editor 50 Introduction and Approach to Headache Bert B. Vargas, MD; and Rashmi B. Halker Singh, MD 51 Primary Headache Disorders: Migraine, Tension-Type, and Chronic Daily Headaches Hossein Ansari, MD; and F. Michael Cutrer, MD 52 Primary Headache Disorders: Trigeminal Autonomic Cephalgias, Headaches With Specific Triggers, and Other Primary Headache Disorders Rashmi B. Halker Singh, MD; and Bert B. Vargas, MD 53 Secondary Headache Disorders Amaal J. Starling, MD; and David W. Dodick, MD 54 Clinical Pain Disorders James C. Watson, MD Questions and Answers Section X: Neuro-oncology and Paraneoplastic Disorders Alyx B. Porter, MD, editor 55 Introduction to Neoplastic Disease Kelly D. Flemming, MD; and Alyx B. Porter, MD 56 Glial Tumors Derek R. Johnson, MD 57 Nonglial Central Nervous System Tumors Heather E. Leeper, MD; and Alyx B. Porter, MD 58 Spinal Cord Tumors Joon H. Uhm, MD 59 Peripheral Nerve Sheath Tumors Mark E. Jentoft, MD 60 Metastatic Disease Alyx B. Porter, MD 61 Neurologic Complications of Radiation and Chemotherapy Gretchen E. Schlosser Covell, MD; and Alyx B. Porter,MD 62 Paraneoplastic and Other Autoimmune Neurologic Disorders Andrew McKeon, MB, BCh, MD Questions and Answers Section XI: Neurologic Infectious Disease Allen J. Aksamit Jr, MD, editor 63 Syndromic Approach to Neuroinfectious Diseases Jennifer A. Tracy, MD 64 DNA and RNA Viral Infections of the Nervous System Michel Toledano, MD; and Allen J. Aksamit Jr, MD 65 Retroviral Infections of the Nervous System Michel Toledano, MD; and Allen J. Aksamit Jr, MD 66 Bacterial Infections of the Nervous System Mark N. Rubin, MD; and Allen J. Aksamit Jr, MD 67 Fungal Infections of the Central Nervous System John W. Wilson, MD 68 Parasitic Infections of the Central Nervous System Shamir Haji, MD; and Allen J. Aksamit Jr, MD 69 Prion Disorders: Creutzfeldt-Jakob Disease and Related Disorders Jeremy K. Cutsforth-Gregory, MD; and Allen J. Aksamit Jr, MD Questions and Answers Section XII: Pediatric Neurology Lilly C. Wong-Kisiel, MD, editor 70 Malformation of the Brain, Skull, and Spine Lilly C. Wong-Kisiel, MD 71 Neurologic Development and Developmental Disabilities Katherine C. Nickels, MD 72 Neurocutaneous Disorders Gesina F. Keating, MD 73 Neurometabolic Disorders Associated With Disturbances of Small Molecule Metabolism Deborah L. Renaud, MD 74 Lysosomal Storage Disorders Radhika Dhamija, MBBS; and Lily C. Wong-Kisiel, MD 75 Inherited Leukoencephalopathies Deborah L. Renaud, MD 76 Mitochondrial Disease Radhika Dhamija, MBBS; and Ralitza Gavrilova, MD Questions and Answers Section XIII: Neurologic Complications of Medical Diseases Neeraj Kumar, MD, editor 77 Electrolyte Disturbance and Acid-Base Imbalance Sara E. Hocker, MD 78 Neurologic Complications of Nutritional Disorders 747 Brent P. Goodman, MD 79 Endocrine Disease 753 William D. Freeman, MD 80 Neurologic Complications of Cardiac, Pulmonary, Renal, Hepatobiliary, and Hematologic Disease 761 William D. Freeman, MD 81 Intoxications and Nontraumatic Neurologic Injury 771 Sara E. Hocker, MD 82 Neurology of Pregnancy 779 Deena M. Nasr, DO; and Lyell K. Jones Jr, MD Questions and Answers 785 Section XIV: Sleep Disorders Pablo R. Castillo, MD, editor 83 Polysomnography and Other Sleep Testing 791 Pablo R. Castillo, MD; and Michael F. Presti, MD, PhD 84 Neuropharmacology of Sleep 795 Pablo R. Castillo, MD 85 Clinical Sleep-Related Breathing Disorders Vichaya Arunthari, MD; and Mara Cvejic, DO 86 Hypersomnias and Sleep-Related Movement Disorders Vichaya Arunthari, MD; and Mara Cvejic, DO 87 Circadian Disorders, Insomnia, and Parasomnias Vichaya Arunthari, MD 88 Sleep Disorders in Infants and Children Mara Cvejic, DO Questions and Answers Section XV: Neurology in Clinical Practice Lyell K. Jones Jr, MD, editor 89 Neuroethics Jimmy R. Fulgham, MD 90 Interpersonal and Communication Skills Mark C. Lee, MD 91 Guide to Maintenance of Certification Lyell K. Jones Jr, MD Questions and Answers Index
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