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Brain Disorders in Critical Illness
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$152.96
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$137.67
$125.15
Practical review of the pathophysiology of brain dysfunction and a thorough account of the diagnostic and therapeutic options available.
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9781107029194
Brain dysfunction is a major clinical problem in intensive care, with potentially debilitating long-term consequences for post-ICU patients of any age. The resulting extended length of stay in the ICU and post-discharge cognitive dysfunction are now recognized as major healthcare burdens. This concise clinical text provides intensivists and neurologists with a practical review of the pathophysiology of brain dysfunction and a thorough account of the diagnostic and therapeutic options available. Initial sections review the epidemiology, outcomes, relevant behavioral neurology and biological mechanisms of brain dysfunction. Subsequent sections evaluate the available diagnostic options and preventative and therapeutic interventions, with a final section on clinical encephalopathy syndromes encountered in the ICU. Each chapter is rich in illustrations, with an executive summary and a helpful glossary of terms. Brain Disorders in Critical Illness is a seminal reference for all physicians and neuroscientists interested in the care and outcome of severely ill patients.
| Author | Edited by Robert D. Stevens , Tarek Sharshar , E. Wesley Ely |
|---|---|
| Table Of Content | Foreword Introduction Glossary Part I. Epidemiology and Outcomes: 1. The epidemiology of critical illness brain dysfunction 2. Cognitive dysfunction following critical illness 3. Psychiatric disorders following critical illnesses 4. Functional status and quality of life after critical illness 5. Delirium and dementia: unraveling the complex relationship Part II. Behavioral Neurology in the ICU: 6. Cognitive reserve 7. Neurology of consciousness impairments 8. Mechanisms of attention and attentional impairment 9. Neurology of sleep and sleep disorders 10. Neural basis of fear and anxiety Part III. Biological Mechanisms: 11. Experimental models of cognitive dysfunction in infection and critical illness 12. Neurobiological effects of systemic physiological and metabolic insults 13. Cerebral ischemia and reperfusion 14. Brain perfusion and autoregulation in systemic critical illness 15. Delirium and neurotransmitter dysfunction 16. Neuromodulatory and neurotoxic effects of sedative agents 17. Neuroimmunological crosstalk in critical illness 18. Inflammatory mechanisms in chronic neurodegenerative disease: the impact of microglia priming 19. The neuroendocrine response to critical illness 20. Autonomic dysfunction in SIRS and sepsis 21. Sepsis-induced neuronal dysfunction and death 22. Neuroimmunomodulation in sepsis Part IV. Diagnosis of Brain Dysfunction: 23. Clinical neurological assessment of the critically ill patient 24. Bedside assessment of delirium in critically ill patients 25. Electroencephalography and evoked potentials in critically ill patients 26. Neuroimaging of delirium Part V. Preventative and Therapeutic Interventions: 27. Environmental modification 28. New paradigms in sedation of the critically ill patient 29. Pharmacological management of delirium 30. Pharmacogenomics and cerebral dysfunction 31. Early physical and occupational therapy 32. Rehabilitation after critical illness Part VI. Clinical Encephalopathy Syndromes: 33. Drug-induced encephalopathy 34. Metabolic encephalopathies: inborn errors of metabolism causing encephalopathies in adults 35. Encephalopathy associated with alcohol or drug withdrawal 36. Posterior reversible encephalopathy syndrome (PRES): the essential elements 37. Hypoxic ischemic encephalopathy 38. Sepsis-associated encephalopathy 39. Seizures and status epilepticus in critical illness 40. Encephalopathy and coma in acute liver failure and chronic liver failure 41. Neurologic complications of cardiac surgery: stroke, encephalopathy, and cognitive decline Index. |
| Format | Hardback |
| Publish Date | 19 Sep 2013 |
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